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>   home   >   Products   >   Primary Antibodies   >   CENPF / CENP-F Antibody (C-Terminus)   

CENPF / CENP-F Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - CENPF / CENP-F Antibody (C-Terminus) ALS12596
    Anti-CENPF antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P49454
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 368kDa
Dilution ELISA (1:64000), IHC-P (3.75 µg/ml),
Additional Information
Gene ID 1063
Other Names Centromere protein F, CENP-F, AH antigen, Kinetochore protein CENPF, Mitosin, CENPF
Target/Specificity Human CENPF. The immunizing peptide shows one mismatch with the corresponmding sequence of the NCBI-curated isoform NP_057427.3.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsCENPF / CENP-F Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CENPF
Function Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.
Cellular Location Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Relocalizes to the kinetochore/centromere (coronal surface of the outer plate) and the spindle during mitosis. Observed in nucleus during interphase but not in the nucleolus. At metaphase becomes localized to areas including kinetochore and mitotic apparatus as well as cytoplasm By telophase, is concentrated within the intracellular bridge at either side of the mid-body
Citations (0)

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Background

Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.

References

Liao H.,et al.J. Cell Biol. 130:507-518(1995).
Zhu X.,et al.Mol. Cell. Biol. 15:5017-5029(1995).
Gregory S.G.,et al.Nature 441:315-321(2006).
Li Q.,et al.Biochem. Biophys. Res. Commun. 212:220-228(1995).
Zhu X.,et al.J. Biol. Chem. 270:19545-19550(1995).

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$ 395.00
Cat# ALS12596
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