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MCAD / ACADM Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • WB - MCAD / ACADM Antibody (C-Terminus) ALS12597
    Antibody staining (0.05 ug/ml) of Human Heart lysate (RIPA buffer, 35 ug total protein per lane).
    detail
  • IHC - MCAD / ACADM Antibody (C-Terminus) ALS12597
    Anti-ACADM antibody IHC of human adrenal.
    detail
  • IHC - MCAD / ACADM Antibody (C-Terminus) ALS12597
    Anti-ACADM antibody IHC of human adrenal.
    detail
  • IHC - MCAD / ACADM Antibody (C-Terminus) ALS12597
    Anti-ACADM antibody IHC of human liver.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P11310
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 47kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.01-0.1 µg/ml)
Additional Information
Gene ID 34
Other Names Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, MCAD, 1.3.8.7, ACADM
Target/Specificity Human ACADM. This antibody is expected to recognise both reported isoforms.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsMCAD / ACADM Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACADM (HGNC:89)
Function Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:1970566, PubMed:8823175, PubMed:21237683, PubMed:2251268). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:2251268). Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:25416781, PubMed:15159392). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains (PubMed:1970566, PubMed:8823175, PubMed:21237683, PubMed:2251268).
Cellular Location Mitochondrion matrix
Research Areas
Citations (0)
citation

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Background

This enzyme is specific for acyl chain lengths of 4 to 16.

References

Kelly D.P.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:4068-4072(1987).
Zhang Z.F.,et al.Biochemistry 31:81-89(1992).
Sun F.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).

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Discontinued
Cat# ALS12597
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