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NR1H2 / LXR Beta Antibody (N-Terminus)

Goat Polyclonal Antibody

     
  • WB - NR1H2 / LXR Beta Antibody (N-Terminus) ALS12601
    Antibody (1 ug/ml) staining of human bone marrow lysate (35 ug protein in RIPA buffer).
  • IHC - NR1H2 / LXR Beta Antibody (N-Terminus) ALS12601
    Anti-NR1H2 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P55055
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 51kDa
Dilution ELISA (1:64000), IHC-P (3 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 7376
Other Names Oxysterols receptor LXR-beta, Liver X receptor beta, Nuclear receptor NER, Nuclear receptor subfamily 1 group H member 2, Ubiquitously-expressed nuclear receptor, NR1H2, LXRB, NER, UNR
Target/Specificity Human NR1H2. Based on the peptide used, this antibody is expected to be specific for LXR beta and not to cross-react with LXR alpha.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsNR1H2 / LXR Beta Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR1H2
Synonyms LXRB, NER, UNR
Function Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Background

Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).

References

Shinar D.M.,et al.Gene 147:273-276(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Song C.,et al.Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
Farnegardh M.,et al.J. Biol. Chem. 278:38821-38828(2003).

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$ 395.00
Cat# ALS12601
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