|Application ||IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse, Dog|
|Dilution||ELISA (1:32000), IHC-P (4 µg/ml),|
|Other Names||High mobility group protein HMG-I/HMG-Y, HMG-I(Y), High mobility group AT-hook protein 1, High mobility group protein A1, High mobility group protein R, HMGA1, HMGIY|
|Target/Specificity||Human HMGA1. This antibody is expected to recognise isoform a (also called HMG-I; NP_665906.1; NP_665908.1) and isoform b (also called HMG-Y; NP_002122.1; NP_665909.1; NP_665910.1; NP_665912.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||HMGIY / HMGA1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.|
|Cellular Location||Nucleus. Chromosome.|
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Provided below are standard protocols that you may find useful for product applications.
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Eckner R.,et al.Nucleic Acids Res. 17:5947-5959(1989).
Johnson K.R.,et al.Mol. Cell. Biol. 9:2114-2123(1989).
Friedmann M.,et al.Nucleic Acids Res. 21:4259-4267(1993).
Nagpal S.,et al.J. Biol. Chem. 274:22563-22568(1999).
Mungall A.J.,et al.Nature 425:805-811(2003).
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