|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:16000), IHC-P (4 µg/ml), WB (1-3 µg/ml)|
|Other Names||Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD295, LEPR, DB, OBR|
|Target/Specificity||Human LEPR / Leptin Receptor. This antibody is expected to recognise all three reported isoforms (NP_002294.2; NP_001003679.1; NP_001003680.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||LEPR / Leptin Receptor Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary Low level in lung and kidney. Isoform B is highly expressed in hypothalamus|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).
Tartaglia L.A.,et al.Cell 83:1263-1271(1995).
Bennett B.D.,et al.Curr. Biol. 6:1170-1180(1996).
Cioffi J.A.,et al.Nat. Med. 2:585-589(1996).
Thompson D.B.,et al.Hum. Mol. Genet. 6:675-679(1997).
Luoh S.-M.,et al.J. Mol. Endocrinol. 18:77-85(1997).
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