|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Pig, Horse, Bovine, Dog|
|Dilution||ELISA (1:128000), IHC-P (4 µg/ml), WB (0.3-1 µg/ml)|
|Other Names||Activin receptor type-1, 22.214.171.124, Activin receptor type I, ACTR-I, Activin receptor-like kinase 2, ALK-2, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, ACVR1, ACVRLK2|
|Target/Specificity||Human ACVR1 / ALK2.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ALK2 / ACVR1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells|
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Provided below are standard protocols that you may find useful for product applications.
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
Matsuzaki K.,et al.J. Biol. Chem. 268:12719-12723(1993).
ten Dijke P.,et al.Oncogene 8:2879-2887(1993).
Oppermann F.S.,et al.Mol. Cell. Proteomics 8:1751-1764(2009).
Umasankar P.K.,et al.Nat. Cell Biol. 14:488-501(2012).
Shore E.M.,et al.Nat. Genet. 38:525-527(2006).
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