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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FOLH1 / PSMA Antibody (clone Y-PSMA1)   

FOLH1 / PSMA Antibody (clone Y-PSMA1)

Mouse Monoclonal Antibody

     
  • IHC - FOLH1 / PSMA Antibody (clone Y-PSMA1) ALS12631
    Anti-FOLH1 / PSMA antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E, IHC-Fr
Primary Accession Q04609
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names Y-PSMA1
Calculated MW 84kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 2346
Other Names Glutamate carboxypeptidase 2, 3.4.17.21, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen, PSM, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase, FOLH1, FOLH, NAALAD1, PSM, PSMA
Target/Specificity Recognizes PSMA expressed in LNCap cell lines. Little or no cross-reactivity to benign prostate hyperplasia (BPH) or to normal prostatic tissue.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsFOLH1 / PSMA Antibody (clone Y-PSMA1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOLH1
Synonyms FOLH, NAALAD1, PSM, PSMA
Function Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.
Cellular Location Cell membrane; Single-pass type II membrane protein
Tissue Location Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-3 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer
Research Areas
Citations (0)

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Background

Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.

References

Israeli R.S.,et al.Cancer Res. 53:227-230(1993).
Su S.L.,et al.Cancer Res. 55:1441-1443(1995).
O'Keefe D.S.,et al.Biochim. Biophys. Acta 1443:113-127(1998).
Luthi-Carter R.,et al.J. Pharmacol. Exp. Ther. 286:1020-1025(1998).
Pangalos M.N.,et al.J. Biol. Chem. 274:8470-8483(1999).

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$ 395.00
Cat# ALS12631
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