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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   F12 / Factor XII Antibody   

F12 / Factor XII Antibody

Goat Polyclonal Antibody

     
  • IHC - F12 / Factor XII Antibody ALS12632
    Anti-F12 / Factor XII antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E, IP, IE
Primary Accession P00748
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 68kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 2161
Other Names Coagulation factor XII, 3.4.21.38, Hageman factor, HAF, Coagulation factor XIIa heavy chain, Beta-factor XIIa part 1, Beta-factor XIIa part 2, Coagulation factor XIIa light chain, F12
Target/Specificity Specific for Factor XII as demonstrated by immunodiffusion. A single precipitin arc was obtained with normal plasma and no reaction was observed with F. XII-deficient plasma.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsF12 / Factor XII Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name F12
Function Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.
Cellular Location Secreted.
Research Areas
Citations (0)

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Background

Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.

References

Cool D.E.,et al.J. Biol. Chem. 262:13662-13673(1987).
Schmutz J.,et al.Nature 431:268-274(2004).
Tripodi M.,et al.Nucleic Acids Res. 14:3146-3146(1986).
Cool D.E.,et al.J. Biol. Chem. 260:13666-13676(1985).
Que B.G.,et al.Biochemistry 25:1525-1528(1986).

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$ 395.00
Cat# ALS12632
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