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APOA1 / Apolipoprotein A 1 Antibody (clone 057-10029)

Mouse Monoclonal Antibody

     
  • IHC - APOA1 / Apolipoprotein A 1 Antibody (clone 057-10029) ALS12634
    Anti-Apolipoprotein A I antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E, RIA
Primary Accession P02647
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 057-10029
Calculated MW 31kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 335
Other Names Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1, Proapolipoprotein A-I, ProapoA-I, Truncated apolipoprotein A-I, Apolipoprotein A-I(1-242), APOA1
Target/Specificity Recognizes Apolipoprotein A-I (Apo A-I). This antibody does not cross-react with Apo A-II or Apo B in competitive RIA.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsAPOA1 / Apolipoprotein A 1 Antibody (clone 057-10029) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APOA1
Function Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Cellular Location Secreted.
Tissue Location Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.
Volume 50 µl
Research Areas
Citations (0)

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Background

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

References

Shoulders C.C.,et al.Nucleic Acids Res. 11:2827-2837(1983).
Cheung P.,et al.Nucleic Acids Res. 11:3703-3715(1983).
Karathanasis S.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:6147-6151(1983).
Seilhamer J.J.,et al.DNA 3:309-317(1984).
Sharpe C.R.,et al.Nucleic Acids Res. 12:3917-3932(1984).

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$ 395.00
Cat# ALS12634
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