|Application ||WB, IHC-P, E|
|Dilution||IHC-P (10 µg/ml), WB (1:1000-1:3000),|
|Other Names||Hsc70-interacting protein, Hip, Aging-associated protein 2, Progesterone receptor-associated p48 protein, Protein FAM10A1, Putative tumor suppressor ST13, Renal carcinoma antigen NY-REN-33, Suppression of tumorigenicity 13 protein, ST13, AAG2, FAM10A1, HIP, SNC6|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||ST13 Antibody (aa1-369, clone AT1F1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||AAG2, FAM10A1, HIP, SNC6|
|Function||One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).
Prapapanich V.,et al.Mol. Endocrinol. 10:420-431(1996).
Mo Y.,et al.Zhonghua Zhong Liu Za Zhi 18:241-243(1996).
Cao J.,et al.J. Cancer Res. Clin. Oncol. 123:447-451(1997).
Kim J.W.,et al.Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
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