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SLC5A1 / SGLT1 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - SLC5A1 / SGLT1 Antibody ALS12642
    Anti-SLC5A1 / SGLT1 antibody IHC of human colon.
    detail
  • IHC - SLC5A1 / SGLT1 Antibody ALS12642
    Anti-SLC5A1 / SGLT1 antibody IHC of human kidney.
    detail
  • WB - SLC5A1 / SGLT1 Antibody ALS12642
    Western blot of SGLT-1 expression in Jurkat cell lysate
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P13866
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 73kDa
Dilution IHC-P (5 µg/ml), WB (0.5-4 µg/ml),
Additional Information
Gene ID 6523
Other Names Sodium/glucose cotransporter 1, Na(+)/glucose cotransporter 1, High affinity sodium-glucose cotransporter, Solute carrier family 5 member 1, SLC5A1, NAGT, SGLT1
Target/Specificity The antibody detects 73 kD SGLT-1 from human samples and in a lesser extent from mouse and rat samples. A ~50 kD cleavage fragment can also be detected in Jurkat cell lysate.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsSLC5A1 / SGLT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC5A1 {ECO:0000303|PubMed:28974690, ECO:0000312|HGNC:HGNC:11036}
Function Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:35077764, PubMed:8563765, PubMed:34880492). Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (PubMed:8563765) (By similarity). Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity). Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (PubMed:28974690). Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine.
Cellular Location Apical cell membrane; Multi-pass membrane protein
Tissue Location Expressed in intestine (PubMed:2490366). Expressed in endometrial cells (PubMed:28974690).
Volume 250 µl
Research Areas
Citations (0)
citation

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Background

Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.

References

Hediger M.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:5748-5752(1989).
Turk E.,et al.J. Biol. Chem. 269:15204-15209(1994).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham I.,et al.Nature 402:489-495(1999).

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Discontinued
Cat# ALS12642
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