|Application ||WB, IHC-P|
|Dilution||IHC-P (5 µg/ml), WB (0.5-4 µg/ml),|
|Other Names||Sodium/glucose cotransporter 1, Na(+)/glucose cotransporter 1, High affinity sodium-glucose cotransporter, Solute carrier family 5 member 1, SLC5A1, NAGT, SGLT1|
|Target/Specificity||The antibody detects 73 kD SGLT-1 from human samples and in a lesser extent from mouse and rat samples. A ~50 kD cleavage fragment can also be detected in Jurkat cell lysate.|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||SLC5A1 / SGLT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed mainly in intestine and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
Hediger M.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:5748-5752(1989).
Turk E.,et al.J. Biol. Chem. 269:15204-15209(1994).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham I.,et al.Nature 402:489-495(1999).
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