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PHAP1 / ANP32A Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - PHAP1 / ANP32A Antibody (N-Terminus) ALS12674
    Anti-ANP32A antibody IHC of human brain, cortex.
    detail
  • IHC - PHAP1 / ANP32A Antibody (N-Terminus) ALS12674
    Anti-ANP32A antibody IHC of human kidney.
    detail
  • IHC - PHAP1 / ANP32A Antibody (N-Terminus) ALS12674
    Anti-ANP32A antibody IHC of human liver.
    detail
  • ICC - PHAP1 / ANP32A Antibody (N-Terminus) ALS12674
    Immunocytochemistry of PHAP in Raji cells with PHAP antibody at 1 µg/ml.
    detail
  • WB - PHAP1 / ANP32A Antibody (N-Terminus) ALS12674
    Western blot of PHAP expression in human Raji cell lysate with PHAP antibody at 1 ug/ml.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, E
Primary Accession P39687
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 29kDa
Dilution ICC (1 µg/ml), IHC-P (5 µg/ml), WB (0.5-2 µg/ml)
Additional Information
Gene ID 8125
Other Names Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32, pp32, Leucine-rich acidic nuclear protein, LANP, Mapmodulin, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A, Putative HLA-DR-associated protein I, PHAPI, ANP32A, C15orf1, LANP, MAPM, PHAP1
Target/Specificity Synthetic peptide corresponding to amino acids at amino terminus of human PHAP
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsPHAP1 / ANP32A Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANP32A
Synonyms C15orf1, LANP, MAPM, PHAP1
Function Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:16341127, PubMed:11360199, PubMed:18439902, PubMed:10400610). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone- acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114).
Cellular Location Nucleus. Cytoplasm Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm. {ECO:0000250, ECO:0000269|PubMed:18180367}
Tissue Location Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala
Research Areas
Citations (0)
citation

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Background

Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression.

References

Vaesen M.,et al.Biol. Chem. Hoppe-Seyler 375:113-126(1994).
Li M.,et al.Biochemistry 35:6998-7002(1996).
Chen T.-H.,et al.Mol. Biol. Cell 7:2045-2056(1996).
Matilla A.,et al.Nature 389:974-978(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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Discontinued
Cat# ALS12674
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