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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   BECN1 / Beclin-1 Antibody (N-Terminus)   

BECN1 / Beclin-1 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - BECN1 / Beclin-1 Antibody (N-Terminus) ALS12683
    Anti-BECN1 / Beclin-1 antibody IHC of human heart.
  • IHC - BECN1 / Beclin-1 Antibody (N-Terminus) ALS12683
    Anti-BECN1 / Beclin-1 antibody IHC of human kidney.
  • IHC - BECN1 / Beclin-1 Antibody (N-Terminus) ALS12683
    Anti-BECN1 / Beclin-1 antibody IHC of human lung, respiratory epithelium.
  • WB - BECN1 / Beclin-1 Antibody (N-Terminus) ALS12683
    Western blot of Beclin-1 in 293 cell lysate with Beclin-1 antibody at (A) 0.5, (B) 1 and (C) 2...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q14457
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 52kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 8678
Other Names Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, BECN1, GT197
Target/Specificity 17 amino acid peptide from near the amino terminus of human Beclin-1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsBECN1 / Beclin-1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BECN1
Synonyms GT197
Function Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3- C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:O88597, ECO:0000269|PubMed:19713971, ECO:0000269|PubMed:21364619}. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Endosome {ECO:0000250|UniProtKB:O88597}. Cytoplasmic vesicle, autophagosome. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity) {ECO:0000250|UniProtKB:O88597, ECO:0000269|PubMed:19050071} Beclin-1-C 37 kDa: Mitochondrion {ECO:0000250|UniProtKB:O88597}
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Background

Plays a central role in autophagy (PubMed:23184933). Required for the abcission step in cytokinesis (PubMed:20208530). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.

References

Liang X.H.,et al.J. Virol. 72:8586-8596(1998).
Aita V.M.,et al.Genomics 59:59-65(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Rommens J.M.,et al.Genomics 28:530-542(1995).
Itakura E.,et al.Mol. Biol. Cell 19:5360-5372(2008).

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$ 395.00
Cat# ALS12683
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