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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   PSENEN / PEN-2 Antibody (N-Terminus)   

PSENEN / PEN-2 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - PSENEN / PEN-2 Antibody (N-Terminus) ALS12686
    Immunofluorescence of PEN2 in Rat Lung cells with PEN2 antibody at 20 ug/ml.
  • IHC - PSENEN / PEN-2 Antibody (N-Terminus) ALS12686
    Anti-PEN2 antibody IHC of human adrenal.
  • IHC - PSENEN / PEN-2 Antibody (N-Terminus) ALS12686
    Anti-PEN2 antibody IHC of human thymus.
  • WB - PSENEN / PEN-2 Antibody (N-Terminus) ALS12686
    Western blot of PEN2 in A-20 cell lysate with ALS12686 at (A) 0.5 and (B) 1 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9NZ42
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 12kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 55851
Other Names Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2, PSENEN, PEN2
Target/Specificity 13 amino acid peptide from near the amino terminus of human PEN2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsPSENEN / PEN-2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSENEN
Synonyms PEN2
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Tissue Location Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
Research Areas
Citations (0)

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Background

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.

References

Zhao M.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Steiner H.,et al.J. Biol. Chem. 277:39062-39065(2002).
Francis R.,et al.Dev. Cell 3:85-97(2002).
Luo W.-J.,et al.J. Biol. Chem. 278:7850-7854(2003).

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$ 395.00
Cat# ALS12686
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