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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TOCA1 / FNBP1L Antibody (C-Terminus)   

TOCA1 / FNBP1L Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - TOCA1 / FNBP1L Antibody (C-Terminus) ALS12693
    Western blot of TOCA-1 in mouse brain tissue lysate with in (A) the absence and (B) the presence...
  • IF - TOCA1 / FNBP1L Antibody (C-Terminus) ALS12693
    Immunofluorescence of TOCA-1 in Human Brain cells with TOCA-1 antibody at 20 ug/ml.
  • IHC - TOCA1 / FNBP1L Antibody (C-Terminus) ALS12693
    Anti-FNBP1L / Toca-1 antibody IHC of human kidney.
  • IHC - TOCA1 / FNBP1L Antibody (C-Terminus) ALS12693
    Anti-FNBP1L / Toca-1 antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q5T0N5
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 70kDa
Dilution IHC-P (2.5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 54874
Other Names Formin-binding protein 1-like, Transducer of Cdc42-dependent actin assembly protein 1, Toca-1, FNBP1L, C1orf39, TOCA1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsTOCA1 / FNBP1L Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FNBP1L
Synonyms C1orf39, TOCA1
Function Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Research Areas
Citations (0)

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Background

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.

References

Ho H.-Y.H.,et al.Cell 118:203-216(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Itoh T.,et al.Dev. Cell 9:791-804(2005).
Aspenstroem P.,et al.Exp. Cell Res. 312:2180-2194(2006).

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$ 395.00
Cat# ALS12693
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