ITPR2 / IP3 Receptor Type 2 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
---|---|
Primary Accession | Q14571 |
Reactivity | Human, Monkey |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 308kDa |
Dilution | ELISA (1:128000), IHC-P (3.75 µg/ml), |
Gene ID | 3709 |
---|---|
Other Names | Inositol 1, 4, 5-trisphosphate receptor type 2, IP3 receptor isoform 2, IP3R 2, InsP3R2, Type 2 inositol 1, 4, 5-trisphosphate receptor, Type 2 InsP3 receptor, ITPR2 |
Target/Specificity | Human ITPR2. No cross-reactivity expected with other types of ITPR. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | ITPR2 / IP3 Receptor Type 2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ITPR2 |
---|---|
Function | Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Isoform Short is found in skeletal muscle and heart |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).
References
Yamamoto-Hino M.,et al.Recept. Channels 2:9-22(1994).
Futatsugi A.,et al.Biochem. J. 334:559-563(1998).
Scherer S.E.,et al.Nature 440:346-351(2006).
Yang J.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:7711-7716(2002).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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