|Application ||IHC-P, E|
|Dilution||ELISA (1:128000), IHC-P (3.75 µg/ml),|
|Other Names||Inositol 1, 4, 5-trisphosphate receptor type 2, IP3 receptor isoform 2, IP3R 2, InsP3R2, Type 2 inositol 1, 4, 5-trisphosphate receptor, Type 2 InsP3 receptor, ITPR2|
|Target/Specificity||Human ITPR2. No cross-reactivity expected with other types of ITPR.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ITPR2 / IP3 Receptor Type 2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Isoform Short is found in skeletal muscle and heart|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).
Yamamoto-Hino M.,et al.Recept. Channels 2:9-22(1994).
Futatsugi A.,et al.Biochem. J. 334:559-563(1998).
Scherer S.E.,et al.Nature 440:346-351(2006).
Yang J.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:7711-7716(2002).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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