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KCNJ11 / Kir6.2 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - KCNJ11 / Kir6.2 Antibody (Internal) ALS12724
    Anti-KCNJ11 / Kir6.2 antibody IHC of human pancreas.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q14654
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 44kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.1-0.3 µg/ml)
Additional Information
Gene ID 3767
Other Names ATP-sensitive inward rectifier potassium channel 11, IKATP, Inward rectifier K(+) channel Kir6.2, Potassium channel, inwardly rectifying subfamily J member 11, KCNJ11
Target/Specificity Human KCNJ11 / Kir6.2. This antibody is expected to recognise isoform 1 (NP_000516.3) only.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsKCNJ11 / Kir6.2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNJ11
Function This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
Cellular Location Membrane; Multi-pass membrane protein.
Research Areas
Citations (0)

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Background

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

References

Inagaki N.,et al.Science 270:1166-1170(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Babenko A.P.,et al.Circ. Res. 83:1132-1143(1998).
Ribalet B.,et al.Biophys. J. 84:266-276(2003).

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$ 395.00
Cat# ALS12724
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