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EGR2 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P11161 |
| Reactivity | Human, Rabbit, Monkey, Pig, Horse, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 50kDa |
| Dilution | ELISA (1:64000), IHC-P (3.75 µg/ml), WB (0.03-0.1 µg/ml) |
| Gene ID | 1959 |
|---|---|
| Other Names | E3 SUMO-protein ligase EGR2, 6.3.2.-, AT591, Early growth response protein 2, EGR-2, Zinc finger protein Krox-20, EGR2, KROX20 |
| Target/Specificity | Human EGR2. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | EGR2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EGR2 |
|---|---|
| Synonyms | KROX20 |
| Function | Sequence-specific DNA-binding transcription factor (PubMed:17717711). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2- consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P08152}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.
References
Joseph L.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:7164-7168(1988).
Joseph L.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:515-515(1989).
Warner L.E.,et al.Nat. Genet. 18:382-384(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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