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SFN / Stratifin / 14-3-3 Sigma Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - SFN / Stratifin / 14-3-3 Sigma Antibody (N-Terminus) ALS12744
    Anti-SFN / 14-3-3 Sigma antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P31947
Reactivity Human, Mouse, Rat, Rabbit, Chicken, Sheep, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 28kDa
Dilution IHC-P (1:250)
Additional Information
Gene ID 2810
Other Names 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1
Target/Specificity Recognizes 14-3-3 sigma in all mammals. It is a member of the 14-3-3 family which consists of 30 kD proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription ...
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsSFN / Stratifin / 14-3-3 Sigma Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SFN
Synonyms HME1
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Cellular Location Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway
Tissue Location Present mainly in tissues enriched in stratified squamous keratinizing epithelium
Research Areas
Citations (0)

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Background

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.

References

Prasad G.L.,et al.Cell Growth Differ. 3:507-513(1992).
Leffers H.,et al.J. Mol. Biol. 231:982-998(1993).
Hermeking H.,et al.Mol. Cell 1:3-11(1997).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 395.00
Cat# ALS12744
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