|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:8000), IHC-P (5 µg/ml), WB (1-2 µg/ml)|
|Other Names||Nucleotide exchange factor SIL1, BiP-associated protein, BAP, SIL1|
|Target/Specificity||Human SIL1. Variants (NP_071909.1; NP_001032722.1) encode the same isoform.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||BAP / SIL1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.|
|Cellular Location||Endoplasmic reticulum lumen|
|Tissue Location||Highly expressed in tissues which produce large amounts of secreted proteins such as kidney, liver and placenta. Also expressed in colon, heart, lung, ovary, pancreas, peripheral leukocyte, prostate, spleen and thymus. Expressed at low levels throughout the brain.|
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Provided below are standard protocols that you may find useful for product applications.
Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.
Tyson J.R.,et al.EMBO J. 19:6440-6452(2000).
Chung K.T.,et al.J. Biol. Chem. 277:47557-47563(2002).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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