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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   BAD Antibody (N-Terminus, clone BYC001)   

BAD Antibody (N-Terminus, clone BYC001)

Mouse Monoclonal Antibody

     
  • IHC - BAD Antibody (N-Terminus, clone BYC001) ALS12750
    Anti-BAD antibody IHC of human adrenal.
  • IHC - BAD Antibody (N-Terminus, clone BYC001) ALS12750
    Anti-BAD antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession Q92934
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names BYC001
Calculated MW 18kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 572
Other Names Bcl2-associated agonist of cell death, BAD, Bcl-2-binding component 6, Bcl-2-like protein 8, Bcl2-L-8, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, BAD, BBC6, BCL2L8
Target/Specificity Recognizes human Bad, Mr 23kD, and mouse Bad, Mr 31kD. Occasionally a Mr 14kD protein is detected in human lysates.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsBAD Antibody (N-Terminus, clone BYC001) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAD
Synonyms BBC6, BCL2L8
Function Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Cellular Location Mitochondrion outer membrane. Cytoplasm {ECO:0000250|UniProtKB:Q61337}. Note=Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm. {ECO:0000250|UniProtKB:Q61337}
Tissue Location Expressed in a wide variety of tissues.
Research Areas
Citations (0)

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Background

Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

References

Yin D.X.,et al.Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
Wang H.-G.,et al.Cell 87:629-638(1996).
Takayama S.,et al.Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
Ottilie S.,et al.J. Biol. Chem. 272:30866-30872(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS12750
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