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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MAdCAM-1 Antibody (clone 314G8, Low Endotoxin)   

MAdCAM-1 Antibody (clone 314G8, Low Endotoxin)

Mouse Monoclonal Antibody

     
  • IHC - MAdCAM-1 Antibody (clone 314G8, Low Endotoxin) ALS12759
    Anti-MADCAM1 antibody IHC of human colon.
  • IHC - MAdCAM-1 Antibody (clone 314G8, Low Endotoxin) ALS12759
    Anti-MADCAM1 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, Flo
Primary Accession Q13477
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 314G8
Calculated MW 40kDa
Dilution Flo (1:10-1:100), IHC-P (10 µg/ml),
Additional Information
Gene ID 8174
Other Names Mucosal addressin cell adhesion molecule 1, MAdCAM-1, hMAdCAM-1, MADCAM1
Target/Specificity Recognizes human mucosal addressin cell adhesion molecule 1 (MAdCAM-1), a 60kD cell surface protein that is involved in lymphocyte trafficking. MAdCAM-1 is expressed on high endothelial venules of Peyers patches and mesenteric lymph nodes. MAdCAM-1 e ...
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles. Store undiluted.
PrecautionsMAdCAM-1 Antibody (clone 314G8, Low Endotoxin) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MADCAM1
Function Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes
Research Areas
Citations (0)

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Background

Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.

References

Leung E.,et al.Immunol. Cell Biol. 74:490-496(1996).
Shyjan A.M.,et al.J. Immunol. 156:2851-2857(1996).
Leung E.,et al.Immunogenetics 46:111-119(1997).
Wang P.Z.,et al.Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).

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$ 395.00
Cat# ALS12759
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