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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CD79A Antibody (N-Terminus)   

CD79A Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - CD79A Antibody (N-Terminus) ALS12765
    Anti-CD79A antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P11912
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 25kDa
Dilution IHC-P (1:100-1:200)
Additional Information
Gene ID 973
Other Names B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein, CD79a, CD79A, IGA, MB1
Reconstitution & Storage Store at 2°C to 8°C degrees. Do not freeze.
PrecautionsCD79A Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD79A
Synonyms IGA, MB1
Function Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Tissue Location B-cells.
Volume 250 µl
Research Areas
Citations (0)

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Background

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

References

Leduc I.,et al.Clin. Exp. Immunol. 90:141-146(1992).
Mueller B.S.,et al.Eur. J. Immunol. 22:1621-1625(1992).
Flaswinkel H.,et al.Immunogenetics 36:266-269(1992).
Yu L.M.,et al.J. Immunol. 148:633-637(1992).
Ha H.J.,et al.J. Immunol. 148:1526-1531(1992).

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$ 395.00
Cat# ALS12765
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