|Reactivity||Human, Mouse, Rat|
|Other Names||Tumor necrosis factor ligand superfamily member 6, Apoptosis antigen ligand, APTL, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL, CD178, Tumor necrosis factor ligand superfamily member 6, membrane form, Tumor necrosis factor ligand superfamily member 6, soluble form, Receptor-binding FasL ectodomain, Soluble Fas ligand, sFasL, ADAM10-processed FasL form, APL, FasL intracellular domain, FasL ICD, SPPL2A-processed FasL form, SPA, FASLG, APT1LG1, CD95L, FASL, TNFSF6|
|Reconstitution & Storage||Store at 2°C to 8°C degrees. Do not freeze.|
|Precautions||FASLG / Fas Ligand Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||APT1LG1, CD95L, FASL, TNFSF6|
|Function||Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane FasL intracellular domain: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into the nucleus|
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Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
Alderson M.,et al.J. Exp. Med. 181:71-77(1995).
Takahashi T.,et al.Int. Immunol. 6:1567-1574(1994).
Schaetzlein C.E.,et al.Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
Mita E.,et al.Biochem. Biophys. Res. Commun. 204:468-474(1994).
Zeytun A.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
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