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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MMP14 Antibody (aa160-173)   

MMP14 Antibody (aa160-173)

Rabbit Polyclonal Antibody

     
  • IHC - MMP14 Antibody (aa160-173) ALS12778
    Anti-MMP14 antibody IHC of human breast.
  • IHC - MMP14 Antibody (aa160-173) ALS12778
    Anti-MMP14 antibody IHC of human colon.
  • IHC - MMP14 Antibody (aa160-173) ALS12778
    Anti-MMP14 antibody IHC of human heart.
  • IHC - MMP14 Antibody (aa160-173) ALS12778
    Anti-MMP14 antibody IHC of human lung, respiratory epithelium.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P50281
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 66kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 4323
Other Names Matrix metalloproteinase-14, MMP-14, 3.4.24.80, MMP-X1, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, MMP14
Reconstitution & Storage Store at 2°C to 8°C degrees. Do not freeze.
PrecautionsMMP14 Antibody (aa160-173) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP14
Function Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2.
Cellular Location Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm
Tissue Location Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors
Volume 250 µl
Research Areas
Citations (0)

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Background

Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2.

References

Sato H.,et al.Nature 370:61-65(1994).
Takino T.,et al.Gene 155:293-298(1995).
Okada A.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:2730-2734(1995).
Will H.,et al.Eur. J. Biochem. 231:602-608(1995).
Luo G.-X.,et al.Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12778
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