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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CSE1L Antibody (N-Terminus)   

CSE1L Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - CSE1L Antibody (N-Terminus) ALS12784
    Anti-CSE1L antibody IHC of human colon.
  • IHC - CSE1L Antibody (N-Terminus) ALS12784
    Anti-CSE1L antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P55060
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 110kDa
Dilution IHC-P (10 µg/ml), WB (0.5-2 µg/ml),
Additional Information
Gene ID 1434
Other Names Exportin-2, Exp2, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Importin-alpha re-exporter, CSE1L, CAS, XPO2
Reconstitution & Storage Store at 2°C to 8°C degrees. Do not freeze.
PrecautionsCSE1L Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSE1L
Synonyms CAS, XPO2
Function Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm
Tissue Location Highly expressed in proliferating cells.
Volume 250 µl
Research Areas
Citations (0)

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Background

Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

References

Brinkmann U.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:10427-10431(1995).
Brinkmann U.,et al.Genomics 58:41-49(1999).
Jiang M.C.,et al.Mol. Cell Biol. Res. Commun. 4:353-358(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).

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$ 395.00
Cat# ALS12784
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