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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CREBBP / CREB Binding Protein Antibody (aa2422-2441)   

CREBBP / CREB Binding Protein Antibody (aa2422-2441)

Rabbit Polyclonal Antibody

     
  • IHC - CREBBP / CREB Binding Protein Antibody (aa2422-2441) ALS12791
    Anti-CREBBP antibody IHC of human breast.
  • IHC - CREBBP / CREB Binding Protein Antibody (aa2422-2441) ALS12791
    Anti-CREBBP antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q92793
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 265kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 1387
Other Names CREB-binding protein, 2.3.1.48, CREBBP, CBP
Reconstitution & Storage Store at 2°C to 8°C degrees. Do not freeze.
PrecautionsCREBBP / CREB Binding Protein Antibody (aa2422-2441) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CREBBP
Synonyms CBP
Function Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902).
Cellular Location Cytoplasm. Nucleus. Note=Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus
Volume 250 µl
Research Areas
Citations (0)

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Background

Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2- ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.

References

Sobulo O.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8732-8737(1997).
Giles R.H.,et al.Genomics 42:96-114(1997).
Petrij F.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Nakajima D.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12791
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