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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   ID3 Antibody (C-Terminus)   

ID3 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - ID3 Antibody (C-Terminus) ALS12796
    Anti-ID3 antibody IHC of human adrenal.
  • IHC - ID3 Antibody (C-Terminus) ALS12796
    Anti-ID3 antibody IHC of human lung.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q02535
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 13kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 3399
Other Names DNA-binding protein inhibitor ID-3, Class B basic helix-loop-helix protein 25, bHLHb25, Helix-loop-helix protein HEIR-1, ID-like protein inhibitor HLH 1R21, Inhibitor of DNA binding 3, Inhibitor of differentiation 3, ID3, 1R21, BHLHB25, HEIR1
Reconstitution & Storage Store at 2°C to 8°C degrees. Do not freeze.
PrecautionsID3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ID3
Synonyms 1R21, BHLHB25, HEIR1
Function Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
Cellular Location Nucleus.
Tissue Location Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain
Volume 500 µl
Research Areas
Citations (0)

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Background

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.

References

Ellmeier W.,et al.EMBO J. 11:2563-2571(1992).
Deed R.W.,et al.Oncogene 8:599-607(1993).
Deed R.W.,et al.Gene 151:309-314(1994).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS12796
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