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Mucin 2 / MUC2 Antibody (clone SPM512)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q02817 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | SPM512 |
| Calculated MW | 540kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 4583 |
|---|---|
| Other Names | Mucin-2, MUC-2, Intestinal mucin-2, MUC2, SMUC |
| Reconstitution & Storage | Store at 2°C to 8°C degrees. Do not freeze. |
| Precautions | Mucin 2 / MUC2 Antibody (clone SPM512) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MUC2 {ECO:0000303|PubMed:8300571, ECO:0000312|HGNC:HGNC:7512} |
|---|---|
| Function | Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (PubMed:17058067, PubMed:19432394, PubMed:33031746). Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine (PubMed:19432394, PubMed:33031746). MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange (PubMed:33031746, PubMed:36206754). Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells (PubMed:36206754). Binds both Cu(2+) and its reduced form, Cu(1+), at two juxtaposed binding sites: Cu(2+), once reduced to Cu(1+) by vitamin C (ascorbate) or other dietary antioxidants, transits to the other binding site (PubMed:36206754). MUC2-bound Cu(1+) is protected from oxidation in aerobic environments, and can be released for nutritional delivery to cells (PubMed:36206754). Mucin gels store antimicrobial molecules that participate in innate immunity (PubMed:33031746). Mucin glycoproteins also house and feed the microbiome, lubricate tissue surfaces, and may facilitate the removal of contaminants and waste products from the body (PubMed:33031746). Goblet cells synthesize two forms of MUC2 mucin that differ in branched chain O-glycosylation and the site of production in the colon: a (1) 'thick' mucus that wraps the microbiota to form fecal pellets is produced in the proximal, ascending colon (By similarity). 'Thick' mucus transits along the descending colon and is lubricated by a (2) 'thin' MUC2 mucus produced in the distal colon which adheres to the 'thick' mucus (By similarity). |
| Cellular Location | Secreted. Note=In the intestine, secreted into the inner and outer mucus layers (By similarity). Before secretion, mucin polymers are stored in dedicated secretory vesicles (PubMed:33031746). {ECO:0000250|UniProtKB:Q80Z19, ECO:0000269|PubMed:33031746} |
| Tissue Location | Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder. |
| Volume | 250 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
References
Gum J.R. Jr.,et al.J. Biol. Chem. 269:2440-2446(1994).
Gum J.R. Jr.,et al.J. Biol. Chem. 267:21375-21383(1992).
Toribara N.W.,et al.J. Clin. Invest. 88:1005-1013(1991).
Gum J.R. Jr.,et al.J. Biol. Chem. 264:6480-6487(1989).
Xu G.,et al.Biochem. Biophys. Res. Commun. 183:821-828(1992).
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