BRAP2 / IMP Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
---|---|
Primary Accession | Q7Z569 |
Reactivity | Human, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 67kDa |
Dilution | ELISA (1:1000), IHC-P (10 µg/ml), |
Gene ID | 8315 |
---|---|
Other Names | BRCA1-associated protein, 6.3.2.-, BRAP2, Impedes mitogenic signal propagation, IMP, RING finger protein 52, Renal carcinoma antigen NY-REN-63, BRAP (HGNC:1099), RNF52 |
Target/Specificity | KLH conjugated synthetic peptide comprising amino acids 27 - 39 [AAGEMSDEEIKKT] of the human BRCA1 associated protein (BRAP) [N-terminus] protein. |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | BRAP2 / IMP Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BRAP (HGNC:1099) |
---|---|
Synonyms | RNF52 |
Function | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. |
Cellular Location | Cytoplasm. |
Tissue Location | Expressed in breast epithelial cell lines. |
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Background
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
References
Li S.,et al.J. Biol. Chem. 273:6183-6189(1998).
Matheny S.A.,et al.Nature 427:256-260(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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