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STYK1 Antibody (clone 2H2F10)

Mouse Monoclonal Antibody

     
  • IHC - STYK1 Antibody (clone 2H2F10) ALS12835
    Anti-STYK1 antibody IHC of human adrenal.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q6J9G0
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2H2F10
Calculated MW 48kDa
Dilution ELISA (1:10000), IHC-P (1:200), WB (1:500-1:2000)
Additional Information
Gene ID 55359
Other Names Tyrosine-protein kinase STYK1, 2.7.10.2, Novel oncogene with kinase domain, Protein PK-unique, Serine/threonine/tyrosine kinase 1, STYK1, NOK
Target/Specificity Ni-NTA purified truncated recombinant STYK1-His is expressed in E. Coli strain BL21 (DE3)
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsSTYK1 Antibody (clone 2H2F10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STYK1
Synonyms NOK
Function Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
Cellular Location Membrane; Single-pass membrane protein
Tissue Location Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers
Research Areas
Citations (0)
citation

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Background

Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).

References

Ye X.,et al.Mol. Biol. Rep. 30:91-96(2003).
Liu L.,et al.Cancer Res. 64:3491-3499(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Scherer S.E.,et al.Nature 440:346-351(2006).

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Discontinued
Cat# ALS12835
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