|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:10000), IHC-P (1:200), WB (1:500-1:2000)|
|Other Names||Alpha-crystallin B chain, Alpha(B)-crystallin, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component, CRYAB, CRYA2|
|Target/Specificity||Purified full length recombinant CRYAB-Trx(aa1-175) is expressed in E. coli strain BL21 (DE3).|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||CRYAB / Alpha B Crystallin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326) Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373).|
|Tissue Location||Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
Kramps J.A.,et al.FEBS Lett. 74:82-84(1977).
Dubin R.A.,et al.Genomics 7:594-601(1990).
Iwaki A.,et al.Neurosci. Lett. 140:89-92(1992).
Yu W.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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