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CBR3 Antibody (clone AT3C5)

Mouse Monoclonal Antibody

     
  • IHC - CBR3 Antibody (clone AT3C5) ALS12850
    Anti-CBR3 antibody IHC of human brain, cortex, white matter.
    detail
  • IHC - CBR3 Antibody (clone AT3C5) ALS12850
    Anti-CBR3 antibody IHC of human small intestine.
    detail
  • IHC - CBR3 Antibody (clone AT3C5) ALS12850
    Anti-CBR3 antibody IHC of human prostate.
    detail
  • WB - CBR3 Antibody (clone AT3C5) ALS12850
    Western analysis of HepG2 cell lysate.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O75828
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names AT3C5
Calculated MW 31kDa
Dilution IHC-P (5 µg/ml), WB (1:1000-1:2000),
Additional Information
Gene ID 874
Other Names Carbonyl reductase [NADPH] 3, 1.1.1.184, NADPH-dependent carbonyl reductase 3, CBR3
Target/Specificity CBR3 (1-277aa)
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsCBR3 Antibody (clone AT3C5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBR3 (HGNC:1549)
Function Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols (PubMed:18493841). Has low NADPH- dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin (PubMed:18493841, PubMed:15537833, PubMed:19841672). Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19841672). Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified (PubMed:19841672).
Cellular Location Cytoplasm.
Tissue Location Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).

References

Watanabe K.,et al.Genomics 52:95-100(1998).
Shimizu N.,et al.Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
Terada T.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Hattori M.,et al.Nature 405:311-319(2000).

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Discontinued
Cat# ALS12850
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