|Application ||WB, IHC-P|
|Reactivity||Human, Monkey, Horse, Bovine|
|Dilution||IHC-P (2.5 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Regulator of G-protein signaling 1, RGS1, B-cell activation protein BL34, Early response protein 1R20, RGS1, 1R20, BL34, IER1|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||RGS1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||1R20, BL34, IER1|
|Function||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.|
|Tissue Location||B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high|
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Provided below are standard protocols that you may find useful for product applications.
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Hong J.X.,et al.J. Immunol. 150:3895-3904(1993).
Newton J.S.,et al.Biochim. Biophys. Acta 1216:314-316(1993).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
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