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>   home   >   Products   >   Primary Antibodies   >   KMT2B / MLL4 Antibody (C-Terminus)   

KMT2B / MLL4 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - KMT2B / MLL4 Antibody (C-Terminus) ALS12854
    Anti-MLL4 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q9UMN6
Reactivity Human, Mouse, Rat, Zebrafish, Monkey, Pig, Bovine
Host Goat
Clonality Polyclonal
Calculated MW 294kDa
Dilution ELISA (1:128000), IHC-P (5 µg/ml),
Additional Information
Gene ID 9757
Other Names Histone-lysine N-methyltransferase 2B, Lysine N-methyltransferase 2B, 2.1.1.43, Myeloid/lymphoid or mixed-lineage leukemia protein 4, Trithorax homolog 2, WW domain-binding protein 7, WBP-7, KMT2B, HRX2, KIAA0304, MLL2, MLL4, TRX2, WBP7
Target/Specificity Human MLL4.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsKMT2B / MLL4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KMT2B
Synonyms HRX2, KIAA0304, MLL2, MLL4, TRX2, WBP7
Function Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.
Cellular Location Nucleus.
Tissue Location Widely expressed. Highest levels in testis. Also found in brain, bone marrow, heart, muscle, kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocytes and pancreas. Often amplified in pancreatic carcinomas
Citations (0)

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Background

Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.

References

Angrand P.-O.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Huntsman D.G.,et al.Oncogene 18:7975-7984(1999).
Nagase T.,et al.DNA Res. 4:141-150(1997).
FitzGerald K.T.,et al.Genomics 59:187-192(1999).

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$ 395.00
Cat# ALS12854
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