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15-PGDH / HPGD Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - 15-PGDH / HPGD Antibody (C-Terminus) ALS12858
    Anti-HPGD / 15-PGDH antibody IHC of human colon.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P15428
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 29kDa
Dilution ELISA (1:128000), IHC-P (2.5 µg/ml), WB (0.1-1 µg/ml)
Additional Information
Gene ID 3248
Other Names 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 15-PGDH, 1.1.1.141, Prostaglandin dehydrogenase 1, HPGD, PGDH1
Target/Specificity Human HPGD / 15-PGDH.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
Precautions15-PGDH / HPGD Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HPGD (HGNC:5154)
Synonyms PGDH1, SDR36C1
Function Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (PubMed:8086429, PubMed:10837478, PubMed:16828555, PubMed:16757471, PubMed:21916491, PubMed:25586183). Decreases the levels of the pro- proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression (PubMed:25586183, PubMed:15574495). Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (PubMed:16757471, PubMed:22844113).
Cellular Location Cytoplasm.
Tissue Location Detected in colon epithelium (at protein level).
Research Areas
Citations (0)
citation

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Background

Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.

References

Krook M.,et al.Biochemistry 29:738-743(1990).
Ensor C.M.,et al.J. Biol. Chem. 265:14888-14891(1990).
Pichaud F.,et al.Gene 162:319-322(1995).
Delage-Mourroux R.,et al.Gene 188:143-148(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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Discontinued
Cat# ALS12858
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