|Application ||IHC-P, IHC-Fr, Flo|
|Reactivity||Human, Mouse, Rat, Hamster, Pig, Sheep, Bovine, Dog|
|Clone Names||Ks 18.04|
|Dilution||IHC-Fr, IHC-P (1:10),|
|Other Names||Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18|
|Target/Specificity||Reacts on cultured lines HeLa and MCf-7. Polypeptide reacting: Mr 45,000 polypeptide of all simple type epithelial and basal cells of many squamous, nonepidermal epithelia.|
|Reconstitution & Storage||Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.|
|Precautions||KRT18 / CK18 / Cytokeratin 18 Antibody (clone Ks 18.04, FITC) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.|
|Cellular Location||Cytoplasm, perinuclear region. Nucleus, nucleolus|
|Tissue Location||Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.|
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Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Oshima R.G.,et al.Differentiation 33:61-68(1986).
Kim J.W.,et al.Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Kulesh D.A.,et al.Mol. Cell. Biol. 8:1540-1550(1988).
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