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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   VWF / Von Willebrand Factor Antibody   

VWF / Von Willebrand Factor Antibody

Rabbit Polyclonal Antibody

     
  • IHC - VWF / Von Willebrand Factor Antibody ALS12887
    Anti-VWF antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, IHC-Fr
Primary Accession P04275
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 309kDa
Dilution IHC-Fr, IHC-P (5 µg/ml),
Additional Information
Gene ID 7450
Other Names von Willebrand factor, vWF, von Willebrand antigen 2, von Willebrand antigen II, VWF, F8VWF
Target/Specificity Recognizes the human Factor VIII Related Antigen. Specifically reacts with the cytoplasm of human endothelial cells from normal and neoplastic blood and from lymphatic vessels. Also reacts with human endocardium, platelets and megakaryocytes. Factor ...
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsVWF / Von Willebrand Factor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VWF
Synonyms F8VWF
Function Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Cellular Location Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage granules
Tissue Location Plasma.
Research Areas
Citations (0)

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Background

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

References

Bonthron D.,et al.Nucleic Acids Res. 14:7125-7128(1986).
Mancuso D.J.,et al.J. Biol. Chem. 264:19514-19527(1989).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Verweij C.L.,et al.EMBO J. 5:1839-1847(1986).

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$ 395.00
Cat# ALS12887
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