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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Basigin / Emmprin / CD147 Antibody (clone OX114)   

Basigin / Emmprin / CD147 Antibody (clone OX114)

Rat Monoclonal Antibody

     
  • IHC - Basigin / Emmprin / CD147 Antibody (clone OX114) ALS12888
    Anti-CD147 antibody IHC of mouse spleen.
  • IHC - Basigin / Emmprin / CD147 Antibody (clone OX114) ALS12888
    Anti-CD147 antibody IHC of mouse testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, Flo
Primary Accession P35613
Reactivity Mouse
Host Rat
Clonality Monoclonal
Clone Names OX114
Calculated MW 42kDa
Dilution Flo (1 µg/10E6 cells), IHC-P (10 µg/ml),
Additional Information
Gene ID 682
Other Names Basigin, 5F7, Collagenase stimulatory factor, Extracellular matrix metalloproteinase inducer, EMMPRIN, Leukocyte activation antigen M6, OK blood group antigen, Tumor cell-derived collagenase stimulatory factor, TCSF, CD147, BSG
Target/Specificity CD147 is a widely expressed membrane glycoprotein (also known as OX47, basigin, EMMPRIN and HT7) and has been implicated in matrix metalloproteinase induction, cell adhesion, retinal cell development and T cell activation. The transmembrane region ha ...
Reconstitution & Storage Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.
PrecautionsBasigin / Emmprin / CD147 Antibody (clone OX114) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BSG
Function Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
Cellular Location Cell membrane; Single- pass type I membrane protein Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In spermatozoa, localized on the principal piece of caput and in the middle piece during transit in the corpus and cauda epididymides (By similarity). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:17081065}
Tissue Location Present only in vascular endothelium in non- neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas
Research Areas
Citations (0)

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Background

Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.

References

Kasinrerk W.,et al.J. Immunol. 149:847-854(1992).
Miyauchi T.,et al.J. Biochem. 110:770-774(1991).
Biswas C.,et al.Cancer Res. 55:434-439(1995).
Wakasugi H.,et al.Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
Decastro R.,et al.Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12888
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