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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   CASP9 / Caspase 9 Antibody (clone 2-22)   

CASP9 / Caspase 9 Antibody (clone 2-22)

Mouse Monoclonal Antibody

     
  • IHC - CASP9 / Caspase 9 Antibody (clone 2-22) ALS12896
    Anti-Caspase 9 antibody IHC of human spleen.
  • IHC - CASP9 / Caspase 9 Antibody (clone 2-22) ALS12896
    Anti-Caspase 9 antibody IHC of human uterus, vessels.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession P55211
Reactivity Human, Monkey
Host Mouse
Clonality Monoclonal
Clone Names 2-22
Calculated MW 46kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 842
Other Names Caspase-9, CASP-9, 3.4.22.62, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, APAF-3, ICE-like apoptotic protease 6, ICE-LAP6, Caspase-9 subunit p35, Caspase-9 subunit p10, CASP9, MCH6
Target/Specificity Detects an ~46-50 kD protein, corresponding to the apparent molecular mass of the caspase-9 on SDS-PAGE immunoblots, in samples from human and monkey origins. This antibody recognizes the pro-caspase-9 human recombinant protein as well as pro-caspase ...
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCASP9 / Caspase 9 Antibody (clone 2-22) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP9
Synonyms MCH6
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).
Tissue Location Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Research Areas
Citations (0)

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Background

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).

References

Duan H.,et al.J. Biol. Chem. 271:16720-16724(1996).
Srinivasula S.M.,et al.J. Biol. Chem. 271:27099-27106(1996).
Hadano S.,et al.Mamm. Genome 10:757-760(1999).
Srinivasula S.M.,et al.Cancer Res. 59:999-1002(1999).
Izawa M.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12896
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