YWHAE / 14-3-3 Epsilon Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P62258 |
Reactivity | Human, Mouse, Rat, Rabbit, Chicken, Bovine, Sheep |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 29kDa |
Dilution | IHC-P (1:400), WB (1:3000), |
Gene ID | 7531 |
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Other Names | 14-3-3 protein epsilon, 14-3-3E, YWHAE |
Target/Specificity | Recognizes the acetylated N-terminal of 14-3-3 epsilon. It is a member of the 14-3-3 family which consists of 30 kD proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structur ... |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | YWHAE / 14-3-3 Epsilon Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | YWHAE |
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Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). |
Cellular Location | Nucleus. Cytoplasm Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Volume | Array |
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Background
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
References
Conklin D.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:7892-7896(1995).
Chong S.S.,et al.Genome Res. 6:735-741(1996).
Jin D.-Y.,et al.Nature 382:308-308(1996).
Han D.,et al.Biochem. Biophys. Res. Commun. 396:401-406(2010).
Luk S.C.W.,et al.Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
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