|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Chicken, Sheep, Bovine|
|Dilution||IHC-P (1:400), WB (1:3000),|
|Other Names||14-3-3 protein epsilon, 14-3-3E, YWHAE|
|Target/Specificity||Recognizes the acetylated N-terminal of 14-3-3 epsilon. It is a member of the 14-3-3 family which consists of 30 kD proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structur ...|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||YWHAE / 14-3-3 Epsilon Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.|
|Cellular Location||Cytoplasm. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
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Provided below are standard protocols that you may find useful for product applications.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Conklin D.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:7892-7896(1995).
Chong S.S.,et al.Genome Res. 6:735-741(1996).
Jin D.-Y.,et al.Nature 382:308-308(1996).
Han D.,et al.Biochem. Biophys. Res. Commun. 396:401-406(2010).
Luk S.C.W.,et al.Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
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