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YWHAE / 14-3-3 Epsilon Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - YWHAE / 14-3-3 Epsilon Antibody (N-Terminus) ALS12901
    Anti-YWHAE / 14-3-3 Epsilon antibody IHC of human breast.
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P62258
Reactivity Human, Mouse, Rat, Rabbit, Chicken, Bovine, Sheep
Host Rabbit
Clonality Polyclonal
Calculated MW 29kDa
Dilution IHC-P (1:400), WB (1:3000),
Additional Information
Gene ID 7531
Other Names 14-3-3 protein epsilon, 14-3-3E, YWHAE
Target/Specificity Recognizes the acetylated N-terminal of 14-3-3 epsilon. It is a member of the 14-3-3 family which consists of 30 kD proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structur ...
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsYWHAE / 14-3-3 Epsilon Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name YWHAE
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448).
Cellular Location Nucleus. Cytoplasm Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Volume Array
Research Areas
Citations (0)
citation

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Background

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

References

Conklin D.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:7892-7896(1995).
Chong S.S.,et al.Genome Res. 6:735-741(1996).
Jin D.-Y.,et al.Nature 382:308-308(1996).
Han D.,et al.Biochem. Biophys. Res. Commun. 396:401-406(2010).
Luk S.C.W.,et al.Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS12901
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