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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   IL23A / IL-23 p19 Antibody (clone HLT2736)   

IL23A / IL-23 p19 Antibody (clone HLT2736)

Mouse Monoclonal Antibody

     
  • IHC - IL23A / IL-23 p19 Antibody (clone HLT2736) ALS12915
    Anti-IL-23 p19 antibody IHC of human adrenal.
  • IHC - IL23A / IL-23 p19 Antibody (clone HLT2736) ALS12915
    Anti-IL-23 p19 antibody IHC of human lung, vasculature.
  • WB - IL23A / IL-23 p19 Antibody (clone HLT2736) ALS12915
    Linker-free, recombinant human IL-23 was resolved by electrophoresis, transferred to...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9NPF7
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names HLT2736
Calculated MW 21kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 51561
Other Names Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19, IL23A, SGRF
Target/Specificity Human recombinant p40 and p19 with elastin linker
Reconstitution & Storage Store undiluted at 4 degrees C
PrecautionsIL23A / IL-23 p19 Antibody (clone HLT2736) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL23A
Synonyms SGRF
Function Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Cellular Location Secreted. Note=Secreted upon association with IL12B
Tissue Location Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
Volume 50 µl
Research Areas
Citations (0)

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Background

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

References

Oppmann B.,et al.Immunity 13:715-725(2000).
Hirata Y.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Parham C.,et al.J. Immunol. 168:5699-5708(2002).
Pirhonen J.,et al.J. Immunol. 169:5673-5678(2002).

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$ 395.00
Cat# ALS12915
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