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Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | P02656 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 11kDa |
| Dilution | IHC-P (3-6 µg/ml) |
| Gene ID | 345 |
|---|---|
| Other Names | Apolipoprotein C-III, Apo-CIII, ApoC-III, Apolipoprotein C3, APOC3 |
| Target/Specificity | Human APOC3 / Apolipoprotein CIII. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | APOC3 / Apolipoprotein C III Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | APOC3 |
|---|---|
| Function | Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. |
| Cellular Location | Secreted |
| Tissue Location | Liver.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.
References
Protter A.A.,et al.DNA 3:449-456(1984).
Levy-Wilson B.,et al.DNA 3:359-364(1984).
Karathanasis S.K.,et al.J. Lipid Res. 26:451-456(1985).
Sharpe C.R.,et al.Nucleic Acids Res. 12:3917-3932(1984).
Fullerton S.M.,et al.Hum. Genet. 115:36-56(2004).
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