|Application ||IHC-P, E|
|Reactivity||Human, Monkey, Pig, Chicken, Horse, Bovine, Dog|
|Calculated MW||56449 Da|
|Dilution||IHC-P (3-6 µg/ml)|
|Other Names||Neuronal acetylcholine receptor subunit alpha-7, CHRNA7, NACHRA7|
|Target/Specificity||Human CHRNA7. This antibody also reacts with CHRNA7-FAM7A fusion isoform 1 (NP_647536.1) and isoform 2 (NP_683709.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CHRNA7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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