|Application ||IHC-P, E|
|Dilution||IHC-P (3-6 µg/ml)|
|Other Names||Tyrosine-protein kinase transmembrane receptor ROR1, 188.8.131.52, Neurotrophic tyrosine kinase, receptor-related 1, ROR1, NTRKR1|
|Target/Specificity||Human ROR1. This antibody is expected to recognize isoform 1 (NP_005003.2) only.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ROR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A- mediated signaling.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm|
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Provided below are standard protocols that you may find useful for product applications.
Tyrosine-protein kinase receptor whose role is not yet clear.
Masiakowski P.,et al.J. Biol. Chem. 267:26181-26190(1992).
Reddy U.R.,et al.Oncogene 13:1555-1559(1996).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Sjoeblom T.,et al.Science 314:268-274(2006).
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