|Application ||IHC-P, E|
|Reactivity||Human, Monkey, Horse, Dog|
|Dilution||IHC-P (3-6 µg/ml)|
|Other Names||TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killer-activating receptor-associated protein, KAR-associated protein, TYROBP, DAP12, KARAP|
|Target/Specificity||Human TYROBP / DAP12. This antibody is expected to recognize both reported isoforms (NP_003323.1; NP_937758.1)|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||DAP12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.|
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Provided below are standard protocols that you may find useful for product applications.
Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
Lanier L.L.,et al.Nature 391:703-707(1998).
Cantoni C.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Begum N.A.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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