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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DAP12 Antibody   

DAP12 Antibody

Goat Polyclonal Antibody

     
  • IHC - DAP12 Antibody ALS12923
    Anti-TYROBP / DAP12 antibody IHC of human spleen.
  • IHC - DAP12 Antibody ALS12923
    Anti-TYROBP / DAP12 antibody IHC of human uterus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession O43914
Reactivity Human, Monkey, Horse, Dog
Host Goat
Clonality Polyclonal
Calculated MW 12kDa
Dilution IHC-P (3-6 µg/ml)
Additional Information
Gene ID 7305
Other Names TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killer-activating receptor-associated protein, KAR-associated protein, TYROBP, DAP12, KARAP
Target/Specificity Human TYROBP / DAP12. This antibody is expected to recognize both reported isoforms (NP_003323.1; NP_937758.1)
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDAP12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TYROBP
Synonyms DAP12, KARAP
Function Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.
Research Areas
Citations (0)

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Background

Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.

References

Lanier L.L.,et al.Nature 391:703-707(1998).
Cantoni C.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Begum N.A.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS12923
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