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LIME1 / LIME Antibody (aa141-295)

Rabbit Polyclonal Antibody

     
  • IHC - LIME1 / LIME Antibody (aa141-295) ALS12935
    Anti-LIME1 / LIME antibody IHC of human spleen.
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9H400
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 31kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 54923
Other Names Lck-interacting transmembrane adapter 1, Lck-interacting membrane protein, Lck-interacting molecule, LIME1, LIME
Target/Specificity Reacts with the cytoplasmic domain of LIME, a 31 kD Lck-interacting transmembrane adaptor expressed by T cells.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsLIME1 / LIME Antibody (aa141-295) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LIME1
Synonyms LIME
Function Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4- mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
Cellular Location Cell membrane; Single-pass type III membrane protein Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell
Tissue Location Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level)
Research Areas
Citations (0)
citation

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Background

Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.

References

Brdickova N.,et al.J. Exp. Med. 198:1453-1462(2003).
Hur E.M.,et al.J. Exp. Med. 198:1463-1473(2003).
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).

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Discontinued
Cat# ALS12935
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