LCP2 / SLP-76 Antibody (aa216-434)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q13094 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 60kDa |
Dilution | IHC-P (10 µg/ml) |
Gene ID | 3937 |
---|---|
Other Names | Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76, LCP2 |
Target/Specificity | The polyclonal antibody reacts with SLP76, a 76kDa cytosolic adaptor protein that is involved in signaling of various hematopoietic cells, such as T cells, mast cells or neutrophils; in B cells, however, it is replaced by SLP65. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | LCP2 / SLP-76 Antibody (aa216-434) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LCP2 |
---|---|
Function | Involved in T-cell antigen receptor mediated signaling. |
Cellular Location | Cytoplasm. |
Tissue Location | Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in T-cell antigen receptor mediated signaling.
References
Jackman J.K.,et al.J. Biol. Chem. 270:7029-7032(1995).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Moog-Lutz C.,et al.J. Biol. Chem. 276:22375-22381(2001).
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