|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76, LCP2|
|Target/Specificity||The polyclonal antibody reacts with SLP76, a 76kDa cytosolic adaptor protein that is involved in signaling of various hematopoietic cells, such as T cells, mast cells or neutrophils; in B cells, however, it is replaced by SLP65.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||LCP2 / SLP-76 Antibody (aa216-434) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in T-cell antigen receptor mediated signaling.|
|Tissue Location||Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines Not detected in fibroblast or neuroblastoma cell lines|
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Provided below are standard protocols that you may find useful for product applications.
Involved in T-cell antigen receptor mediated signaling.
Jackman J.K.,et al.J. Biol. Chem. 270:7029-7032(1995).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Moog-Lutz C.,et al.J. Biol. Chem. 276:22375-22381(2001).
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