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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LAT2 / NTAL Antibody (aa91-243)   

LAT2 / NTAL Antibody (aa91-243)

Rabbit Polyclonal Antibody

     
  • IHC - LAT2 / NTAL Antibody (aa91-243) ALS12937
    Anti-LAT2 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9GZY6
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 27kDa
Dilution IHC-P (10 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 7462
Other Names Linker for activation of T-cells family member 2, Linker for activation of B-cells, Membrane-associated adapter molecule, Non-T-cell activation linker, Williams-Beuren syndrome chromosomal region 15 protein, Williams-Beuren syndrome chromosomal region 5 protein, LAT2, LAB, NTAL, WBS15, WBSCR15, WBSCR5
Target/Specificity Recognizes the defined epitope (aa 91-243) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kD transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid ...
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsLAT2 / NTAL Antibody (aa91-243) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAT2
Synonyms LAB, NTAL, WBS15, WBSCR15, WBSCR5
Function Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Cellular Location Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts
Tissue Location Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B- cells, NK cells and monocytes. Absent from T-cells (at protein level).
Research Areas
Citations (0)

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Background

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.

References

Doyle J.L.,et al.Cytogenet. Cell Genet. 90:285-290(2000).
Martindale D.W.,et al.Mamm. Genome 11:890-898(2000).
Brdicka T.,et al.J. Exp. Med. 196:1617-1626(2002).
Janssen E.,et al.Nat. Immunol. 4:117-123(2003).
Tassabehji M.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12937
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