|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml), WB (1 µg/ml),|
|Other Names||Linker for activation of T-cells family member 2, Linker for activation of B-cells, Membrane-associated adapter molecule, Non-T-cell activation linker, Williams-Beuren syndrome chromosomal region 15 protein, Williams-Beuren syndrome chromosomal region 5 protein, LAT2, LAB, NTAL, WBS15, WBSCR15, WBSCR5|
|Target/Specificity||Recognizes the defined epitope (aa 91-243) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kD transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid ...|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||LAT2 / NTAL Antibody (aa91-243) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||LAB, NTAL, WBS15, WBSCR15, WBSCR5|
|Function||Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.|
|Cellular Location||Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts|
|Tissue Location||Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B- cells, NK cells and monocytes. Absent from T-cells (at protein level).|
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Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Doyle J.L.,et al.Cytogenet. Cell Genet. 90:285-290(2000).
Martindale D.W.,et al.Mamm. Genome 11:890-898(2000).
Brdicka T.,et al.J. Exp. Med. 196:1617-1626(2002).
Janssen E.,et al.Nat. Immunol. 4:117-123(2003).
Tassabehji M.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
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