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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CRADD / RAIDD Antibody   

CRADD / RAIDD Antibody

Rabbit Polyclonal Antibody

     
  • IHC - CRADD / RAIDD Antibody ALS12940
    Anti-CRADD / RAIDD antibody IHC of human skeletal muscle.
  • IHC - CRADD / RAIDD Antibody ALS12940
    Anti-CRADD / RAIDD antibody IHC of human placenta.
  • IHC - CRADD / RAIDD Antibody ALS12940
    Anti-CRADD / RAIDD antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P78560
Reactivity Human, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 23kDa
Dilution IHC-P (10 µg/ml), WB (1:500),
Additional Information
Gene ID 8738
Other Names Death domain-containing protein CRADD, Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD, RAIDD
Target/Specificity Detects an ~24 kD protein, corresponding to the apparent molecular mass of RAIDD on SDS-PAGE immunoblots. This 24 kD band, as well as a 67 kD band, can be specifically inhibited by the relevant peptide.
Reconstitution & Storage Store at -20°C.
PrecautionsCRADD / RAIDD Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRADD
Synonyms RAIDD
Function Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.
Cellular Location Cytoplasm. Nucleus
Tissue Location Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney
Research Areas
Citations (0)

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Background

Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.

References

Ahmad M.,et al.Cancer Res. 57:615-619(1997).
Duan H.,et al.Nature 385:86-89(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Tinel A.,et al.Science 304:843-846(2004).

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$ 395.00
Cat# ALS12940
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