|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml), WB (1:500),|
|Other Names||Death domain-containing protein CRADD, Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD, RAIDD|
|Target/Specificity||Detects an ~24 kD protein, corresponding to the apparent molecular mass of RAIDD on SDS-PAGE immunoblots. This 24 kD band, as well as a 67 kD band, can be specifically inhibited by the relevant peptide.|
|Reconstitution & Storage||Store at -20°C.|
|Precautions||CRADD / RAIDD Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.
Ahmad M.,et al.Cancer Res. 57:615-619(1997).
Duan H.,et al.Nature 385:86-89(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Tinel A.,et al.Science 304:843-846(2004).
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